Proceeding May03 Overview

Non-linear Dose-Response Relationships in Biology, Toxicology and Medicine
Amherst, Massachusetts
May 28-30, 2003

Sponsors

Samueli Institute
Department of Energy
Food and Drug Administration
Health Canada
Others

Purpose & Focus

To discuss the significance of biological effects of low level exposures. Knowledge of low dose effects is becoming a driving force in the field of risk assessment and chemotherapeutics. The conference provides the most current advances in the area of dose response with respect to chemical and radiation induced stresses and a host of effects of pharmaceutical agents that have profound biomedical implications.

Audience

Basic and clinical scientists, public health providers, government researchers and policy makers.

Outcome

12 individually selected papers presented at the conference were published in a Samueli Institute Proceedings in May 2004.

Table of Contents

FOREWORD FROM THE ORGANIZERS
Edward J. Calabrese, PhD 
Wayne B. Jonas, MD

EDITOR’S COMMENTS
Ronald A. Chez, MD
John A. Ives, PhD

PRACTICAL IMPLICATIONS OF NON-LINEAR EFFECTS IN RISK ASSESSMENT HARMONIZATION
John A. Bukowski
R. Jeffrey Lewis

DOSE-RESPONSE CURVES IN CHEMICAL CARCINOGENESIS
William J. Waddell, MD

DETOXICATION STRATEGY OF EPOXIDE HYDROLASE— THE BASIS FOR A NOVEL THRESHOLD FOR DEFINABLE GENOTOXIC CARCINOGENS
Franz Oesch, Prof. Dr.
Jan Gerog Hengstler, Prof. Dr.
Michael Arand, Prof. Dr.

EVALUATION OF THE EXPOSURE-RESPONSE RELATIONSHIP OF LUNG CANCER MORTALITY AND OCCUPATIONAL EXPOSURE TO HEXAVALENT CHROMIUM BASED ON PUBLISHED EPIDEMIOLOGICAL DATA
Edwin van Wijngaarden, PhD
Kenneth A. Mundt, PhD
Rose S. Luippold, MS

THE USE OF STREPTOLYSIN O FOR THE TREATMENT OF SCARS, ADHESIONS AND FIBROSIS: INITIAL INVESTIGATIONS USING MURINE MODELS OF SCLERODERMA
Stephen W, Mamber, PhD
Vit Long
Ryan G. Rhodes
Sunthorn Pond-Tor
Lyn R. Wheeler
Kellie Fredericks
Brian VanScoy
Jean-Frederic Sauniere
John McMichael
Remy Steinschneider
Jean-Claude Laurent

U-SHAPED DOSE-RESPONSE FUNCTION BETWEEN DEYDROEPIANDRO-TERONE SULFATE (DHEAS) AND MEMORY RELATED PROCESSING BY THE HIPPOCAMPUS
David M. Diamond, PhD

METALLOTHIONEIN AS AN ADAPTIVE PROTEIN PREVENTS DIABETES AND ITS TOXICITY
Lu Cai, MD, PhD

MOLECULAR MECANISMS OF ANTI-AGING HORMETIC EFFECTS OF MILD HEAT STRESS ON HUMAN CELLS
Suresh I.S. Rattan, PhD, DSc 
Yvonne E.G. Eskildsen-Helmond
Rasmus Beedholm

DOSE RESPONSE RELATIONSHIPS IN EXPRESSION OF BIOMARKERS OF CELL PROLIFERATION IN IN VITRO ASSAYS AND INHALATION EXPERIMENTS
Brooke T. Mossman, PhD
Arti Shukla
Pamela Vaceck

MECHANISTIC MODEL PREDICTS LOW-DOSE NON-LINEARITY OF LIVER TUMOR RISK IN MICE FED FUMONISIN B1
Ralph L. Kodell, PhD
Angelo Turturro, PhD

RESPONSES OF CULTURED ASTROCYTES, C6 GLIOMA AND 1321NI ASTROCYTOMA CELLS TO AMYLOID-PEPTIDE FRAGMENTS
V.W. Pentreath, BSc, PhD
C. Mead

EFFECTS OF LOW AND VERY LOW DOSE OF SIMPLE PHENOLICS ON PLANT PEROXIDASE ACTIVITY
Ezbiea Malarczyk, PhD
Janina Kochmanska-Rdest
Marzanna Pazdzioch-Czochra, PhD

Contributing Authors

Michael Arand, Prof. Dr.
Institut für Pharmakologie und Toxikologie
der Universitat

John A. Bukowski
ExxonMobil Biomedical Sciences, Inc.

Lu Cai, M.D., PhD
Department of Medicine
University of Louisville School of Medicine

Edward J. Calabrese, PhD
School of Public Health
Environmental Health Sciences
University of Massachusetts

Ronald A. Chez, MD
Samueli Institute

David M. Diamond, PhD
Depts. of Psychology and Pharmacology
University of South Florida

Jan Geog Hengstler, Prof. Dr.
Universitat Leipzig
Rudolf-Bohem Institut für Pharmakologie und Toxikologie

John A. Ives, PhD
Samueli Institute

Wayne B. Jonas, MD
Samueli Institute

Ralph L. Kodell, PhD
Division of Biometry and Risk Assessment
National Center for Toxicological Research

R. Jeffrey Lewis
ExxonMobil Biomedical Sciences, Inc.

Rose S. Luippold, MS

Elzbieta Malarczyk PhD
Biochemistry Department
M. Curie-Sklodowska University

Stephen W. Mamber, PhD
Milkhaus Laboratory, Inc.

Brook T. Mossman, PhD
Department of Pathology
University of Vermont, College of Medicine

Kenneth A. Mundt, PhD

Franz Oesch, Prof. Dr.
Institute of Toxicology
University of Mainz

Marzanna Pazdzioch-Czochra PhD
Biochemistry Department
M. Curie-Sklodowska University

Victor W. Pentreath, BSc, PhD
Division of Biosciences
University of Salford

Suresh I.S. Rattan, PhD, DSc
Department of Molecular Biology
University of Aarhus

Angelo Turturro, PhD
Division of Biometry and Risk Assessment
National Center for Toxicological Research

William J. Waddell, MD

Edwin van Wijngaarden, PhD

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